Welcome to our blog!

This webpage was created around the article "Structure of the mitotic checkpoint complex " by Chao et.al.

The mitotic checkpoint complex (MCC) is a multiprotein complex that inhibits the activity of APC/C (anaphase promoting complex/cyclosome) and thereby ensures chromosome fidelity. It is an important step in preventing aneuploidy.

For purposes of this blog, we will be analysing the crystal structure of the Schizosaccharomyces pombe MCC.

Video 1: This animation shows the structure of the MCC in Schizosaccharomyces pombe. 

This shows the subunits, Mad3 (magenta), Mad2 (blue) and Cdc20 (green). This was made on Pymol.