References

1. Herzog F, Primorac I, Dube P, et al. Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex. Science. 2009;323(5920):1477-1481.

2. Weaver BAA, Silk AD, Montagna C, Verdier-Pinard P, Cleveland DW. Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell. 2007;11(1):25-36.

3. Ibrahim B. Spindle assembly checkpoint is sufficient for complete Cdc20 sequestering in mitoticcontrol. Computational and Structural Biotechnology Journal. 2015;13:320-328.

4. Chao WCH, Kulkarni K, Zhang Z, Kong EH, Barford D. Structure of the mitotic checkpoint complex. Nature. 2012;484(7393):208-213.

5. Izawa D, Pines J. The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C. Nature. 2015;517(7536):631-634.

6. Ravid T, Hochstrasser M. Diversity of degradation signals in the ubiquitin-proteasomesystem. Nat Rev Mol Cell Biol. 2008;9(9):679-690.

7. He J, Chao W, Zhang Z, Yang J, Cronin N, Barford D. Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex. Molecular Cell. 2013;50(5):649-660. doi:10.1016/j.molcel.2013.04.024.

8. Li C, Zhu Y, Wang Y, Chen G. Molecular Dynamics Simulation on theConformational Transition of the Mad2 Protein from the Open to the ClosedState. IJMS. 2014;15(4):5553-5569. doi:10.3390/ijms15045553.

9. Musacchio A, Salmon E. The spindle-assembly checkpoint in space and time. Nature Reviews Molecular Cell Biology. 2007;8(5):379-393. doi:10.1038/nrm2163.

10. Letunic I, Doerks T, Bork P. SMART: TPR domain annotation. Nucleic Acids Research. 2014;43(D1):D257-D260. doi:10.1093/nar/gku949.